A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus.

@article{Koyama2003ANP,
  title={A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus.},
  author={Tetsuya Koyama and Hiroshi Tsukamoto and Koh-hei Masumoto and Daisuke Himeji and Ken’ichiro Hayashi and M. D. N. Harada and Takahiko Horiuchi},
  journal={Rheumatology},
  year={2003},
  volume={42 8},
  pages={980-5}
}
OBJECTIVE We investigated the association of gene polymorphisms in APRIL, a new member of the TNF family, with systemic lupus erythematosus. METHODS To detect polymorphisms of the human APRIL gene by exon-specific polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis, we first determined the structure of the human APRIL gene. We designed exon-specific oligonucleotide primers according to the genomic DNA sequence of APRIL. All of the coding regions in exons of… CONTINUE READING