A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients.

@article{Wu2003ANP,
  title={A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients.},
  author={Jianming Wu and Christine M Metz and Xiulong Xu and Riichiro Abe and Andrew W. Gibson and Jeffrey C. Edberg and Jennifer R Cooke and Fenglong Xie and G. S. Cooper and Robert Kimberly},
  journal={Journal of immunology},
  year={2003},
  volume={170 1},
  pages={132-8}
}
A single-nucleotide polymorphism (SNP), identified at nucleotide position -844 in the 5' promoter of the FasL gene, lies within a putative binding motif for CAAT/enhancer-binding protein beta (C/EBPbeta). Electrophoretic mobility shift and supershift assays confirmed that this element binds specifically to C/EBPbeta and demonstrated that the two alleles of this element have different affinities for C/EBPbeta. In luciferase reporter assays, the -844C genotype had twice the basal activity of the… CONTINUE READING

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