A novel poly(l-glutamic acid) dendrimer based drug delivery system with both pH-sensitive and targeting functions.

@article{Yuan2010ANP,
  title={A novel poly(l-glutamic acid) dendrimer based drug delivery system with both pH-sensitive and targeting functions.},
  author={Hui Yuan and Kui Luo and Yusi Lai and Yuji Pu and Bin He and Gang Wang and Yao Wu and Zhongwei Gu},
  journal={Molecular pharmaceutics},
  year={2010},
  volume={7 4},
  pages={953-62}
}
The functionalization of pH-sensitiveness and cellular targeting is a promising strategy to fabricate drug delivery systems with high efficiency, high selectivity and low toxicity. In this paper, a poly(l-glutamic acid) dendrimer based drug delivery system with both pH-sensitive and targeting functions is reported. Poly(l-glutamic acid) dendrimers with a polyhedral oligomeric silsesquioxane (POSS) nanocubic core were synthesized. Its globular morphology and compact structure with multiple… CONTINUE READING