A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor.

@article{Podrasky1997ANP,
  title={A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor.},
  author={Ernest Podrasky and David S. Xu and B. T. Liang},
  journal={The American journal of physiology},
  year={1997},
  volume={273 5 Pt 2},
  pages={H2380-7}
}
Although ATP, acting through a P2 purinoceptor, can stimulate a pronounced positive inotropic effect in cardiac ventricular myocytes, the receptor-effector mechanism that underlies this stimulatory cardiac action is not well understood. The objectives of the present study were to develop the cultured chick embryo ventricular myocytes as a novel model for the cardiac P2 purinoceptor and to determine the mechanism underlying its positive inotropic effect. ATP caused an 89 +/- 8.9% (n = 14 cells… CONTINUE READING

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