A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line.

@article{Gao2002ANP,
  title={A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line.},
  author={Sanyang Gao and Tomoko Takano and Kiyonao Sada and Jinsong He and Chiseko Noda and Naoko Hori-Tamura and Akio Tomoda and Hirohei Yamamura},
  journal={British journal of pharmacology},
  year={2002},
  volume={137 6},
  pages={749-55}
}
1. 2-amino-4, 4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one (Phx) has been demonstrated to be an actinomycin D-like phenoxazine, and to display anti-tumour activity. 2. In this study, we report on the effect of Phx on B cell antigen receptor (BCR) and receptor-mediated signalling in DT40 B cells. 3. Treatment of B cells with Phx for 12 h inhibited BCR-stimulated tyrosine phosphorylation of cellular proteins. 4. B cells exposed to Phx exhibited down-regulation of surface IgM which is… CONTINUE READING

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