A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

Abstract

Hematopoietic stem progenitor cells (HSPCs) respond robustly to α-chemokine stromal-derived factor-1 (SDF-1) gradients, and blockage of CXCR4, a seven-transmembrane-spanning GαI-protein-coupled SDF-1 receptor, mobilizes HSPCs into peripheral blood. Although the SDF-1–CXCR4 axis has an unquestionably important role in the retention of HSPCs in bone marrow… (More)
DOI: 10.1038/leu.2011.242

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Cite this paper

@article{Ratajczak2012ANP, title={A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients}, author={Medhi Ratajczak and C. H. Kim and A A Abdel-latif and G. Schneider and Magdalena J. Kucia and A. J. Morris and Michael J. Laughlin and Jan Ratajczak}, journal={Leukemia}, year={2012}, volume={26}, pages={63-72} }