A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential.

@article{Dey2003ANP,
  title={A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential.},
  author={Debendranath Dey and Satya Medicherla and Partha Neogi and Maya Gowri and Jin Cheng and Coleman Gross and Somesh D. Sharma and Gerald Mark Reaven and Bishwajit Nag},
  journal={Metabolism: clinical and experimental},
  year={2003},
  volume={52 8},
  pages={1012-8}
}
Agonists of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) are pharmacologically active antihyperglycemic agents that act by increasing peripheral tissue sensitivity to insulin. Many of these agonists have antihyperglycemic activity that is directly proportional to their ability to bind and activate PPAR gamma; however, recent data bring this relationship into question. In this report we describe a new PPAR gamma agonist, CLX-0921, that is derived from a… CONTINUE READING

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