A novel peroxide-induced calcium transient regulates interleukin-6 expression in cardiac-derived fibroblasts.

@article{Colston2002ANP,
  title={A novel peroxide-induced calcium transient regulates interleukin-6 expression in cardiac-derived fibroblasts.},
  author={James T. Colston and Bysani Chandrasekar and Gregory L. Freeman},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 26},
  pages={23477-83}
}
Reperfusion of ischemic myocardium leads to a local burst of free radicals, increased [Ca(2+)](i), and the release of proinflammatory cytokines. The purpose of this study was to determine whether brief exposure of cardiac fibroblasts to H(2)O(2) is associated with transient changes in [Ca(2+)](i) levels and whether this stimulus is sufficient to induce interleukin-6 (IL-6) expression. Cardiac derived fibroblasts were isolated from adult male rats and cultured under standard conditions… CONTINUE READING

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Peroxide-induced Calcium Transients

K. C. Wollert, H. Drexler
Heart Failure Rev • 2001

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