A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis.

@article{BenHur2001ANP,
  title={A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis.},
  author={Tamir Ben-Hur and Ron Cialic and Anna Itzik and Ohr Barak and Raz Yirmiya and Joseph Weidenfeld},
  journal={Neuroscience},
  year={2001},
  volume={108 1},
  pages={119-27}
}
Herpes simplex virus type 1 (HSV-1) encephalitis may present with fever and behavioral changes, to the extent of a psychotic state and psychomotor agitation. We developed a clinically relevant experimental model of HSV-1 encephalitis and investigated host brain responses associated with its clinical signs and whether these responses depend on the presence of circulating glucocorticoids. Intracerebral inoculation of HSV-1 in rats induced fever, motor hyperactivity and aggressive behavior. In… CONTINUE READING