A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs.

@article{Kimura1990ANP,
  title={A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs.},
  author={Chikashi Kimura and S Ohkubo and Kazuhiro Ogi and Masaki Hosoya and Yoshito Itoh and Haruo Onda and Atsuro Miyata and L Jiang and R R Dahl and H. H. Stibbs},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={166 1},
  pages={81-9}
}
A novel neuropeptide which remarkably stimulates adenylate cyclase in rat anterior pituitary cell cultures has been recently isolated from ovine hypothalami by A. Arimura and his collaborators (Biochem.Biophys.Res.Commun.164, 567-574(1989)). This peptide was designated as PACAP38(Pituitary Adenylate Cyclase Activating Polypeptide with 38 residues). In an attempt to investigate physiological implications of PACAP38, we have succeeded in cloning the cDNAs encoding the precursor of PACAP38 from… CONTINUE READING