A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility.

@article{Mauriello2013ANP,
  title={A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility.},
  author={Clifford T. Mauriello and Haree K. Pallera and Julia A. Sharp and Jon L Woltmann and Shizhi Qian and Pamela S. Hair and Pieter van der Pol and Cees van Kooten and Nicole M Thielens and Frank A. Lattanzio and Kenji M Cunnion and Neel K Krishna},
  journal={Molecular immunology},
  year={2013},
  volume={53 1-2},
  pages={
          132-9
        }
}
Previous experiments from our laboratories have identified peptides derived from the human astrovirus coat protein (CP) that bind C1q and mannose binding lectin (MBL) inhibiting activation of the classical and lectin pathways of complement, respectively. The purpose of this study was to evaluate the function of these coat protein peptides (CPPs) in an in vitro model of complement-mediated disease (ABO incompatibility), preliminarily assess their in vivo complement suppression profile and… CONTINUE READING
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