A novel peptide from the ACEI/BPP-CNP precursor in the venom of Crotalus durissus collilineatus.

@article{Higuchi2006ANP,
  title={A novel peptide from the ACEI/BPP-CNP precursor in the venom of Crotalus durissus collilineatus.},
  author={Shigesada Higuchi and Nobuhiro Murayama and Ken-ichi Saguchi and Hiroaki Ohi and Yoshiaki Fujita and Nelson Jorge Jr Da Silva and Rodrigo Jos{\'e} Bezerra de Siqueira and Saad Lahlou and Steven D Aird},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2006},
  volume={144 2},
  pages={107-21}
}
In crotaline venoms, angiotensin-converting enzyme inhibitors [ACEIs, also known as bradykinin potentiating peptides (BPPs)], are products of a gene coding for an ACEI/BPP-C-type natriuretic peptide (CNP) precursor. In the genes from Bothrops jararaca and Gloydius blomhoffii, ACEI/BPP sequences are repeated. Sequencing of a cDNA clone from venom glands of Crotalus durissus collilineatus showed that two ACEIs/BPPs are located together at the N-terminus, but without repeats. An additional… CONTINUE READING

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