A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects.

@article{Hecht2009ANP,
  title={A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects.},
  author={Iris Hecht and Jiang Rong and Andr{\'e} Luiz Franco Sampaio and Chen Hermesh and Caleb W Rutledge and Ronen Shemesh and Amir Toporik and Merav Beiman and Liat Dassa and Hagit Niv and Gady Cojocaru and Arie Zauberman and G. Rotman and Mauro Perretti and Jakob Vinten-Johansen and Yossi Cohen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={328 2},
  pages={426-34}
}
Activation of the formyl-peptide receptor-like (FPRL) 1 pathway has recently gained high recognition for its significance in therapy of inflammatory diseases. Agonism at FPRL1 affords a beneficial effect in animal models of acute inflammatory conditions, as well as in chronic inflammatory diseases. TIPMFVPESTSKLQKFTSWFM-amide (CGEN-855A) is a novel 21-amino acid peptide agonist for FPRL1 and also activates FPRL2. CGEN-855A was discovered using a computational platform designed to predict novel… CONTINUE READING

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