A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.

Abstract

Chromogranin A (CHGA/Chga), a proprotein, widely distributed in endocrine and neuroendocrine tissues (not expressed in muscle, liver, and adipose tissues), generates at least four bioactive peptides. One of those peptides, pancreastatin (PST), has been reported to interfere with insulin action. We generated a Chga knock-out (KO) mouse by the targeted… (More)
DOI: 10.1074/jbc.M109.020636

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Cite this paper

@article{Gayen2009ANP, title={A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.}, author={Jiaur Rahman Gayen and Maziyar Saberi and Simon Schenk and Nilima Biswas and Sucheta M. Vaingankar and Wai Wilson Cheung and Sonia M Najjar and Daniel T. O'Connor and G. Bandyopadhyay and Sushil K Mahata}, journal={The Journal of biological chemistry}, year={2009}, volume={284 42}, pages={28498-509} }