A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.

@article{Gayen2009ANP,
  title={A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.},
  author={Jiaur Rahaman Gayen and Maziyar Saberi and Simon Schenk and N. B. Ghosh Biswas and Sucheta M Vaingankar and Wai Wilson Cheung and Sonia M Najjar and Daniel T. O'Connor and Gautam Kumar Bandyopadhyay and Sushil K Mahata},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 42},
  pages={28498-509}
}
Chromogranin A (CHGA/Chga), a proprotein, widely distributed in endocrine and neuroendocrine tissues (not expressed in muscle, liver, and adipose tissues), generates at least four bioactive peptides. One of those peptides, pancreastatin (PST), has been reported to interfere with insulin action. We generated a Chga knock-out (KO) mouse by the targeted deletion of the Chga gene in neuroendocrine tissues. KO mice displayed hypertension, higher plasma catecholamine, and adipokine levels and lower… CONTINUE READING