A novel pathway for transcriptional regulation of alpha-synuclein.

  title={A novel pathway for transcriptional regulation of alpha-synuclein.},
  author={Richard Lee Clough and Leonidas Stefanis},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={21 2},
Alpha-synuclein is an abundant neuronal protein that has been linked to both normal synaptic function and neurodegeneration--in particular, Parkinson's disease (PD). Uncovering mechanisms that control alpha-synuclein transcription is therefore critical for PD pathogenesis and synaptic function. We previously reported that in PC12 cells and primary neurons, alpha-synuclein is transcriptionally up-regulated after application of growth factors. In the current work we have characterized the pathway… CONTINUE READING


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