A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.

@article{Shibuya2013ANP,
  title={A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.},
  author={Norihiro Shibuya and Shin Koike and Makiko Tanaka and Mari Ishigami-Yuasa and Yuka Kimura and Yuki Ogasawara and Kiyoshi Fukui and Noriyuki Nagahara and Hideo Kimura},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={1366}
}
In eukaryotes, hydrogen sulphide acts as a signalling molecule and cytoprotectant. Hydrogen sulphide is known to be produced from L-cysteine by cystathionine β-synthase, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase coupled with cysteine aminotransferase. Here we report an additional biosynthetic pathway for the production of hydrogen sulphide from D-cysteine involving 3-mercaptopyruvate sulfurtransferase and D-amino acid oxidase. Unlike the L-cysteine pathway, this D-cysteine… CONTINUE READING
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