A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin.

@article{Slominski2004ANP,
  title={A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin.},
  author={Andrzej T Slominski and Jordan Kordian Zjawiony and Jacobo Wortsman and Igor Semak and Jeremy Stewart and Alexander Pisarchik and Trevor Sweatman and Josep Marcos and Chuck Dunbar and Robert C Tuckey},
  journal={European journal of biochemistry},
  year={2004},
  volume={271 21},
  pages={4178-88}
}
Following up on our previous findings that the skin possesses steroidogenic activity from progesterone, we now show widespread cutaneous expression of the full cytochrome P450 side-chain cleavage (P450scc) system required for the intracellular catalytic production of pregnenolone, i.e. the genes and proteins for P450scc enzyme, adrenodoxin, adrenodoxin reductase and MLN64. Functionality of the system was confirmed in mitochondria from skin cells. Moreover, purified mammalian P450scc enzyme and… CONTINUE READING

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