A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning

@inproceedings{Tang2012ANP,
  title={A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning},
  author={Xianying Tang and Bryan J. St. Germain and Wei-Lih Lee},
  booktitle={The Journal of cell biology},
  year={2012}
}
During mitosis in budding yeast, cortically anchored dynein generates pulling forces on astral microtubules to position the mitotic spindle across the mother-bud neck. The attachment molecule Num1 is required for dynein anchoring at the cell membrane, but how Num1 assembles into stationary cortical patches and interacts with dynein is unknown. We show that an N-terminal Bin/Amphiphysin/Rvs (BAR)-like domain in Num1 mediates the assembly of morphologically distinct patches and its interaction… CONTINUE READING
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