A novel passive dosing system for determining the toxicity of phenanthrene to early life stages of zebrafish.

  title={A novel passive dosing system for determining the toxicity of phenanthrene to early life stages of zebrafish.},
  author={Josh D Butler and Thomas F Parkerton and Daniel J Letinski and Gail E Bragin and Mark Allan Lampi and K. R. Cooper},
  journal={The Science of the total environment},
Reliable experimental early life stage chronic toxicity data for fish are limited and further data are needed for polyaromatic hydrocarbons to establish environmental quality objectives and compare with toxicity model predictions. Efforts are underway to develop a zebrafish embryo toxicity test guideline to reduce, refine and replace the use of vertebrates in animal testing. An adaptation of this method which includes embryo lethal and sub-lethal developmental endpoints after a 5-day exposure… CONTINUE READING
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