A novel parathyroid hormone-related protein: role in pathology and physiology.

@article{Martin1990ANP,
  title={A novel parathyroid hormone-related protein: role in pathology and physiology.},
  author={Thomas J Martin and Peter R. Ebeling},
  journal={Progress in clinical and biological research},
  year={1990},
  volume={332},
  pages={1-37}
}
Many factors, such as interleukin 1, TGF alpha, TNF alpha, and beta and prostaglandins, have been implicated in aetiological roles in HHM (Martin and Mundy, 1987). Much interest in the past has also centered upon the likelihood of ectopic secretion of PTH in this condition. We have purified a protein (PTHrP) implicated in HHM from a human lung cancer cell line (BEN). Full-length cDNA clones have been isolated and found to encode a prepropeptide of 36 amino acids and a mature protein of 141… CONTINUE READING