A novel parasite-derived suicide gene for cancer gene therapy with specificity for lung cancer cells.

@article{Trudeau2001ANP,
  title={A novel parasite-derived suicide gene for cancer gene therapy with specificity for lung cancer cells.},
  author={C. Trudeau and Shi-zhen Yuan and Jacques Galipeau and Naciba Benlimame and Moulay A. Alaoui-Jamali and Gerald Batist},
  journal={Human gene therapy},
  year={2001},
  volume={12 13},
  pages={1673-80}
}
The enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) expressed by the parasite Trypanosoma brucei (Tb) can convert allopurinol, a purine analogue, to corresponding nucleotides with greater efficiency than its human homologue. We have developed a retroviral system that expresses the parasitic enzyme and tested its capacity to activate the prodrug allopurinol to a cytotoxic metabolite. Cytotoxicity assays demonstrated that five non-small cell lung carcinoma cell lines transduced with… CONTINUE READING
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