A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis.

@article{Israeli1997ANP,
  title={A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis.},
  author={David Israeli and Emma Tessler and Ygal Haupt and A Elkeles and Sylvia Wilder and Robert Amson and Adam Telerman and Moshe Oren},
  journal={The EMBO journal},
  year={1997},
  volume={16 14},
  pages={4384-92}
}
The biological effects of the p53 tumor suppressor protein are elicited, at least in part, through sequence-specific transactivation of a battery of target genes. The differential display method was employed towards identifying additional p53 target genes, with emphasis on genes whose induction may contribute to p53-mediated apoptosis. We report here the cloning of a novel p53-inducible gene, designated PAG608. PAG608 transcripts are induced by DNA damage in a p53-dependent manner. PAG608… CONTINUE READING

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