A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).

Abstract

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. We have identified PRG3 (p53-responsive gene 3), which is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells, and encodes a novel polypeptide of 373 amino acids with a predicted molecular mass of 40.5 kDa. PRG3 has… (More)

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Cite this paper

@article{Ohiro2002ANP, title={A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).}, author={Yoichi Ohiro and Igor V. Garkavtsev and Shinichiro Kobayashi and Kodangattil R. Sreekumar and Regan Nantz and Bryan T. Higashikubo and Shannon L Duffy and Ryuji Higashikubo and Anny Usheva and David R. Gius and Nikolai Kley and Nobuo Horikoshi}, journal={FEBS letters}, year={2002}, volume={524 1-3}, pages={163-71} }