A novel oxidative rearrangement of 6-methoxypyran-2-ones.


As part of our continuing studies of pyrone-containing natural products, a series 6-methoxypyran-2-ones were synthesized. These were found to react with molecular oxygen at 20 degrees C, and this novel reaction yielded a series of highly functionalized alpha,beta-butenolides. [reaction: see text] 


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@article{Eade2005ANO, title={A novel oxidative rearrangement of 6-methoxypyran-2-ones.}, author={Serena J Eade and Robert M Adlington and Andrew R. Cowley and Magnus W Walter and Jack E. Baldwin}, journal={Organic letters}, year={2005}, volume={7 17}, pages={3705-7} }