A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.

  title={A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.},
  author={Xiaoming Yao and Ji-Fan Hu and Mark Daniels and Huifan Yien and Hongqi Lu and Hadas Sharan and Xiangjun Zhou and Zhilan Zeng and Tao Li and Youwen Yang and Andrew R Hoffman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={9 7},
An orthotopic xenograft tumor model of hepatocellular carcinoma was created by injection of Hep 3B cells directly into the liver parenchyma of nude mice. Tumors were localized primarily in the injected lobe of the liver, beginning from the third week after tumor cell implantation. Thereafter, tumors grew rapidly, and animals usually died from hepatocellular carcinoma within 2 months. Insulin-like growth factor II, an embryonic growth factor and mitogen, is overexpressed in these tumors at both… CONTINUE READING


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