A novel one-step synthesis of 2-substituted 6-azaindoles from 3-amino-4-picoline and carboxylic esters.
@article{Song2005ANO, title={A novel one-step synthesis of 2-substituted 6-azaindoles from 3-amino-4-picoline and carboxylic esters.}, author={J. Song and Z. Tan and F. Gallou and J. Xu and N. Yee and C. Senanayake}, journal={The Journal of organic chemistry}, year={2005}, volume={70 16}, pages={ 6512-4 } }
Dilithiation of 3-amino-4-picoline (1) was achieved with sec-BuLi at room temperature. Condensation of the resulting dianion (2) with carboxylic esters afforded a wide range of 2-substituted 6-azaindoles in good yields.
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