A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1.

Abstract

Monocarboxylate transporter isoform-1 (MCT1) plays an important role in the absorption of short-chain fatty acids (SCFAs) in the colon. Butyrate, a major SCFA, serves as the primary energy source for the colonic mucosa, maintains epithelial integrity, and ameliorates intestinal inflammation. Previous studies have shown substrate (butyrate)-induced… (More)
DOI: 10.1152/ajpgi.00308.2012

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