A novel nucleotide receptor in Xenopus activates the cAMP second messenger pathway.

@article{Devader2007ANN,
  title={A novel nucleotide receptor in Xenopus activates the cAMP second messenger pathway.},
  author={Christelle Devader and Christian M. Drew and Timothy J. Geach and Jacqui Tabler and Andrea Townsend-Nicholson and Leslie Dale},
  journal={FEBS letters},
  year={2007},
  volume={581 27},
  pages={5332-6}
}
We describe a Xenopus P2Y receptor that shares only weak homology with members of the mammalian P2Y family, being most similar to human P2Y(11). When activated by nucleotide analogs, it stimulates both calcium and cAMP mobilization pathways, a feature unique, among mammalian P2Y receptors, to P2Y(11). Activity can be blocked by compounds known to act as antagonists of mammalian P2Y(11). Genomic synteny between Xenopus and mammals suggests that the novel gene is a true ortholog of P2Y(11… CONTINUE READING

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