A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans.

@article{Zhai2006ANN,
  title={A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans.},
  author={Ruitong Zhai and Geng Meng and Yanmei Zhao and Bin Liu and Genfa Zhang and Xiaofeng Zheng},
  journal={FEBS letters},
  year={2006},
  volume={580 16},
  pages={3811-7}
}
The adrenal gland protein AD-004 like protein (ADLP) from Caenorhabditis elegans was cloned and expressed in Escherichia coli. Enzyme assays showed that ADLP has special adenylate kinase (AK) properties, with ATP and dATP as the preferred phosphate donors. In contrast to all other AK isoforms, AMP and dAMP were the preferred substrates of ADLP; CMP, TMP and shikimate acid were also good substrates. Subcellular localization studies showed a predominant nuclear localization for this protein… CONTINUE READING

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