A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice.

@article{Yamauchi2016ANN,
  title={A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice.},
  author={Keita Yamauchi and Yusuke Nakano and Takahiko Imai and Toshinori Takagi and Kazuhiro Tsuruma and Masamitsu Shimazawa and Toru Iwama and Hideaki Hara},
  journal={Neuroscience},
  year={2016},
  volume={333},
  pages={302-10}
}
Recanalization of occluded vessels leads to ischemia-reperfusion injury (IRI), with oxidative stress as one of the main causes of injury, despite the fact that recanalization therapy is the most effective treatment for ischemic stroke. The nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the transcription factors which has an essential role in protection against oxidative stress. RS9 is a novel Nrf2 activator obtained from bardoxolone methyl (BARD), an Nrf2 activator that has… CONTINUE READING

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