A novel nonsense mutation in PAX9 is associated with sporadic hypodontia.

@article{Zhu2012ANN,
  title={A novel nonsense mutation in PAX9 is associated with sporadic hypodontia.},
  author={Junxia Zhu and Xiang Ping Yang and Chenying Zhang and Lihong Ge and Shuguo Zheng},
  journal={Mutagenesis},
  year={2012},
  volume={27 3},
  pages={313-7}
}
The most important events during the regulation of tooth development were inductive interactions between the epithelial and mesenchymal tissues. The expression of Pax9 had been shown to specifically mark the mesenchymal regions at the prospective sites of all teeth prior to any morphological manifestations. Here, we investigated the PAX9 gene as a candidate… CONTINUE READING