A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease.

@article{Drig2007ANN,
  title={A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease.},
  author={Jan D{\"u}rig and Peter Ebeling and Florian Grabellus and Ursula R Sorg and Michael M{\"o}llmann and Philipp Schuett and Joachim R G{\"o}thert and Ludger Sellmann and Siegfried Seeber and Michael Flasshove and Ulrich D{\"u}hrsen and Thomas Moritz},
  journal={Cancer research},
  year={2007},
  volume={67 18},
  pages={8653-61}
}
We here describe a novel xenograft model of chronic lymphocytic leukemia (CLL) generated by infusion of human primary CLL cells into immunodeficient nonobese/severe combined immunodeficient (NOD/SCID) mice. Combined i.v. and i.p. injection of peripheral blood mononuclear cells (PBMC) from 39 patients with CLL resulted in highly reproducible splenic (37 of 39) and peritoneal (35 of 39) engraftment, which remained stable over a time span of 4 to 8 weeks. By comparison, recovery of leukemic cells… CONTINUE READING