A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease.

@article{Drig2007ANN,
  title={A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease.},
  author={Jan D{\"u}rig and Peter Ebeling and Florian Grabellus and Ursula R Sorg and Michael M{\"o}llmann and Philipp Schuett and Joachim R G{\"o}thert and Ludger Sellmann and Siegfried Seeber and Michael Flasshove and Ulrich D{\"u}hrsen and Thomas Moritz},
  journal={Cancer research},
  year={2007},
  volume={67 18},
  pages={8653-61}
}
We here describe a novel xenograft model of chronic lymphocytic leukemia (CLL) generated by infusion of human primary CLL cells into immunodeficient nonobese/severe combined immunodeficient (NOD/SCID) mice. Combined i.v. and i.p. injection of peripheral blood mononuclear cells (PBMC) from 39 patients with CLL resulted in highly reproducible splenic (37 of… CONTINUE READING