A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine.

@article{Moussa2015ANN,
  title={A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine.},
  author={Maha Mousa Mohamed Moussa and G{\'e}raldine Arrode-Brus{\'e}s and Iliyan Manoylov and Alexander S. Malogolovkin and Dimitri Mompelat and Honorine Ishimwe and Amel Smaoune and Bilel Ouzrout and Jean Pierre Gagnon and Yahia Chebloune},
  journal={Vaccine},
  year={2015},
  volume={33 19},
  pages={
          2273-2282
        }
}
Novel HIV vaccine vectors and strategies are needed to control HIV/AIDS epidemic in humans and eradicate the infection. DNA vaccines alone failed to induce immune responses robust enough to control HIV-1. Development of lentivirus-based DNA vaccines deficient for integration and with a limited replication capacity is an innovative and promising approach. This type of vaccine mimics the early stages of virus infection/replication like the live-attenuated viruses but lacks the inconvenient… CONTINUE READING
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