A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

  title={A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)},
  author={Stephen J. Fuller and Liam James McGuffin and Andrew K. Marshall and Alejandro Giraldo and Sampsa Pikkarainen and Angela Clerk and Peter H. Sugden},
  booktitle={The Biochemical journal},
The canonical pathway of regulation of the GCK (germinal centre kinase) III subgroup member, MST3 (mammalian Sterile20-related kinase 3), involves a caspase-mediated cleavage between N-terminal catalytic and C-terminal regulatory domains with possible concurrent autophosphorylation of the activation loop MST3(Thr(178)), induction of serine/threonine protein kinase activity and nuclear localization. We identified an alternative 'non-canonical' pathway of MST3 activation (regulated primarily… CONTINUE READING

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