A novel non-canonical Wnt signature for prostate cancer aggressiveness

  title={A novel non-canonical Wnt signature for prostate cancer aggressiveness},
  author={E. Sandsmark and A. Hansen and K. Seln{\ae}s and H. Bertilsson and A. Bofin and A. Wright and T. Viset and E. Richardsen and F. Drabl{\o}s and T. Bathen and May-Britt Tessem and M. Rye},
  pages={9572 - 9586}
  • E. Sandsmark, A. Hansen, +9 authors M. Rye
  • Published 2017
  • Medicine
  • Oncotarget
  • Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A newly discovered NCWP, Wnt5/Fzd2, has been shown to induce epithelial-to-mesenchymal transition (EMT) in cancers, but has not been investigated in prostate cancer. The aim of this study was to investigate if the CWP and NCWP, in combination with EMT, are associated with… CONTINUE READING
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