A novel neutrophil-activating factor produced by human mononuclear phagocytes

@article{Peveri1988ANN,
  title={A novel neutrophil-activating factor produced by human mononuclear phagocytes},
  author={Paola Peveri and Alfred Walz and Beatrice Dewald and Marco Baggiolini},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={167},
  pages={1547 - 1559}
}
The biological properties of a neutrophil-activating factor (NAF), which was recently identified as a novel peptide of approximately 6,000 mol wt, are described. NAF is produced de novo by human blood monocytes upon stimulation with LPS, PHA, and Con A. It induces two main responses in human neutrophils, i.e., exocytosis (release from specific granules in normal, and from specific and azurophil granules in cytochalasin B-treated cells) and the respiratory burst (formation of superoxide and… CONTINUE READING

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