A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons.

@article{Arioka2005ANN,
  title={A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons.},
  author={M. Arioka and So-hyun Cheon and Yutaka Ikeno and Satoru Nakashima and Katsuhiko Kitamoto},
  journal={FEBS letters},
  year={2005},
  volume={579 12},
  pages={2693-701}
}
Cultured cerebellar granule neurons (CGNs) require membrane depolarization or neurotrophic factors for their survival in vitro and undergo apoptosis when deprived of these survival-promoting stimuli. Here, we show that secretory phospholipases A(2)s (sPLA(2)s) rescue CGNs from apoptosis after potassium deprivation. The neurotrophic effect required the enzymatic activity of sPLA(2)s, since catalytically inactive mutants of sPLA(2)s failed to protect CGNs from apoptosis. Consistently, the ability… CONTINUE READING