A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity.

@article{Boules2001ANN,
  title={A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity.},
  author={Mona M Boules and Lewis E Warrington and Abdul H. Fauq and Daniel J. Mccormick and Elliott Richelson},
  journal={European journal of pharmacology},
  year={2001},
  volume={426 1-2},
  pages={73-6}
}
Neurotensin is a tridecapeptide that exhibits selective anatomic and neurochemical interactions with dopaminergic systems. Since dopaminergic neurotransmission underlies many of the behavioral properties of psychostimulants, and since neurotensin has been implicated in modulating dopaminergic neurotransmitter systems, we tested the effect of our novel neurotensin analog, NT69L (N-methyl-Arg(8),L-Lys(9),L-neo-Trp(11),tert-Leu(12)]neurotensin-(8-13)), on hyperactivity caused by cocaine and D… CONTINUE READING
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