A novel neuronal cell protecting substance, halxazone, produced by Streptomyces halstedii.

@article{Katoh2002ANN,
  title={A novel neuronal cell protecting substance, halxazone, produced by Streptomyces halstedii.},
  author={Hironobu Katoh and Kazuo Shin‐ya and Kazuo Furihata and Keiko Furihata and Yoichi Hayakawa},
  journal={The Journal of antibiotics},
  year={2002},
  volume={55 5},
  pages={
          508-10
        }
}
Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Although the accurate etiology of Parkinson's disease is not clear, one of the hypothetical factors is oxidative stress. The excess administration of L-DOPA, which is an effective drug in PD therapy, results in the worsening of Parkinson's disease, by generating reactive oxygen species (ROS)1-3). Thus, the advance of PD may be expected to be overcome by substances which suppress… 
2 Citations
Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches.
TLDR
It is postulated that multitargeting therapies comprising antioxidants, cell cycle inhibitors and modulating agents of COX-2 or c-JUN kinase pathways could be suitable strategies to prevent or delay the process of neuronal cell death in neurodegenerative disorders.

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TLDR
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TLDR
The aqueous residue was extracted with EtOAc, and the organic layer was, after drying over Na2SO4, evaporated to give an oily residue.
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TLDR
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TLDR
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TLDR
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TLDR
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