A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

@article{Melov1998ANN,
  title={A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase},
  author={S. Melov and J. Schneider and B. Day and Douglas Hinerfeld and P. Coskun and S. S. Mirra and J. Crapo and D. Wallace},
  journal={Nature Genetics},
  year={1998},
  volume={18},
  pages={159-163}
}
  • S. Melov, J. Schneider, +5 authors D. Wallace
  • Published 1998
  • Biology, Medicine
  • Nature Genetics
  • Reactive oxygen species (ROS) have been implicated in a wide range of degenerative processes including amyotrophic lateral sclerosis, ischemic heart disease, Alzheimer disease, Parkinson disease and aging1–5. ROS are generated by mitochondria as the toxic by-products of oxidative phosphorylation, their energy generating pathway6,7. Genetic inactivation of the mitochondrial form of superoxide dismutase in mice results in dilated cardiomyopathy, hepatic lipid accumulation and early neonatal… CONTINUE READING
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