A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin.

@article{Yoneshima1997ANN,
  title={A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin.},
  author={Hideo Yoneshima and Eiichiro Nagata and Mineo Matsumoto and Masashi Yamada and Kazunori Nakajima and Takaki Miyata and Miyuki Ogawa and Katsuhiko Mikoshiba},
  journal={Neuroscience research},
  year={1997},
  volume={29 3},
  pages={217-23}
}
We present yotari, a novel neurological mutant mouse whose mutation is transmitted in an autosomal recessive manner. The phenotype of yotari is very similar to that of reeler. yotari mutants are recognizable by their unstable gait and tremor and by their early deaths at around the time of weaning. The cerebella of homozygous yotari are hypoplastic and have no foliation. A molecular and a granular cell layer can be identified, but Purkinje cells are scattered throughout both the granular layer… CONTINUE READING

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