A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia.

@article{Hsu2013ANN,
  title={A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia.},
  author={Wei-Hsuan Hsu and Bao-Hong Lee and Yu-Ying Chang and Ya-Wen Hsu and Tzu-Ming Pan},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={272 3},
  pages={842-51}
}
Methylglyoxal (MG) is a toxic-glucose metabolite and a major precursor of advanced glycation endproducts (AGEs). MG has been reported to result in inflammation by activating receptor for AGEs (RAGE). We recently found that Monascus-fermented metabolite monascin acts as a novel natural peroxisome proliferator-activated receptor-γ (PPARγ) agonist that improves insulin sensitivity. We investigated the metabolic, biochemical, and molecular abnormalities characteristic of type 2 diabetes in MG… CONTINUE READING

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