A novel murine model of allogeneic vaccination against prostate cancer

  title={A novel murine model of allogeneic vaccination against prostate cancer},
  author={M P Labarthe and P. Theocharous and Nick Russell and Stephen M Todryk and C. Bangma and Peter Thraves and Angus George Dalgleish and Michael A Whelan},
  journal={Cancer Immunology, Immunotherapy},
Prostate cancer continues to be a major cause of death in men. Surgical and medical treatments of the disease have improved, but metastasic disease remains a significant clinical problem. Novel therapies such as whole cell vaccination offer the potential of treating disease by stimulating the immune system. To study the efficacy of a whole cell vaccine in prostate cancer two strains of mice were used: C57BL/6 (H-2Kb) and C3H/HeJ (H-2Kk) in combination with four different cell lines. Thus, a… CONTINUE READING


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Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response.

Proceedings of the National Academy of Sciences of the United States of America • 2000
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