A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

@inproceedings{Hgerling2013ANM,
  title={A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy},
  author={Ren{\'e} H{\"a}gerling and Cathrin Pollmann and Martin Andreas and Christian Schmidt and Harri Nurmi and Ralf H Adams and Kari Alitalo and Volker Andresen and Stefan Schulte-Merker and Friedemann Kiefer},
  booktitle={The EMBO journal},
  year={2013}
}
During mammalian development, a subpopulation of endothelial cells in the cardinal vein (CV) expresses lymphatic-specific genes and subsequently develops into the first lymphatic structures, collectively termed as lymph sacs. Budding, sprouting and ballooning of lymphatic endothelial cells (LECs) have been proposed to underlie the emergence of LECs from the CV, but the exact mechanisms of lymph vessel formation remain poorly understood. Applying selective plane illumination-based… CONTINUE READING
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Mechanotransduction , PROX 1 , and FOXC 2 Cooperate to Control Connexin 37 and Calcineurin during LymphaticValve Formation

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