A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway.

@article{Hosaka2012ANM,
  title={A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway.},
  author={Seiichi Hosaka and Keisuke Horiuchi and Masaki Yoda and Robert Nakayama and Takahide Tohmonda and Michiro Susa and Masaya Nakamura and Kazuhiro Chiba and Yoshiaki Toyama and Hideo Morioka},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2012},
  volume={30 9},
  pages={1493-8}
}
Synovial sarcoma is an aggressive soft tissue sarcoma with only a modest response to conventional cytotoxic agents. In the present study, we evaluated the potential antitumor effects of a novel anti-angiogenesis agent, pazopanib, against synovial sarcoma cells. We found that pazopanib directly inhibited the growth of synovial sarcoma cells by inducing G1… CONTINUE READING