A novel multi-coaxial hollow fiber bioreactor for adherent cell types. Part 1: hydrodynamic studies.

@article{Wolfe2002ANM,
  title={A novel multi-coaxial hollow fiber bioreactor for adherent cell types. Part 1: hydrodynamic studies.},
  author={Stephen S Wolfe and Edward Hsu and Lola C. M. Reid and Jeffrey M. Macdonald},
  journal={Biotechnology and bioengineering},
  year={2002},
  volume={77 1},
  pages={83-90}
}
A novel multi-coaxial bioreactor for three-dimensional cultures of adherent cell types, such as liver, is described. It is composed of four tubes of increasing diameter placed one inside the other, creating four spatially isolated compartments. Liver acinar structure and physiological parameters are mimicked by sandwiching cells in the space between the two innermost semi-permeable tubes, or hollows fibers, and creating a radial flow of media from an outer compartment (ECC), through the cell… CONTINUE READING

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