A novel mouse model of subcortical infarcts with dementia.

  title={A novel mouse model of subcortical infarcts with dementia.},
  author={Yorito Hattori and Jun-ichiro Enmi and Akihiro Kitamura and Yumi Yamamoto and Satoshi Saito and Yukako Takahashi and Satoshi Iguchi and Masahiro Tsuji and Kenichi Yamahara and Kazuyuki Nagatsuka and Hidehiro Iida and Masafumi Ihara},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={35 9},
Subcortical white matter (WM) is a frequent target of ischemic injury and extensive WM lesions are important substrates of vascular cognitive impairment (VCI) in humans. However, ischemic stroke rodent models have been shown to mainly induce cerebral infarcts in the gray matter, while cerebral hypoperfusion models show only WM rarefaction without infarcts. The lack of animal models consistently replicating WM infarct damage may partially explain why many neuroprotective drugs for ischemic… CONTINUE READING