A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury.

@article{Deng2014ANM,
  title={A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury.},
  author={Guiying Deng and Joan C. Yonchek and Nidia Quillinan and Frank A Strnad and Jennifer Exo and Paco S. Herson and Richard J. Traystman},
  journal={Journal of neuroscience methods},
  year={2014},
  volume={222},
  pages={34-41}
}
BACKGROUND Pediatric sudden cardiac arrest (CA) is an unfortunate and devastating condition, often leading to poor neurologic outcomes. However, little experimental data on the pathophysiology of pediatric CA is currently available due to the scarcity of animal models. NEW METHOD We developed a novel experimental model of pediatric cardiac arrest and cardiopulmonary resuscitation (CA/CPR) using postnatal day 20-25 mice. Adult (8-12 weeks) and pediatric (P20-25) mice were subjected to 6min CA… CONTINUE READING